p53 is the most calculated biomolecule in the history of molecular environmental science with over 70,000 study papers written on it since its invention in 1979. p53 plays a vital role in confirming that there is no disorder while cell division takes places.
If a cell makes a mistake in copying its DNA during the process of splitting, p53 stops it in its tracks, summons a repair team before allowing the cell to carry on division, thus helping in prevention of cancer. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide, said Sue Armstrong in her extensively popular book written exclusively on this molecule, p53 – the gene that helped cracking the cancer code.
It is this capacity to order a rogue cell to commit suicide that makes us safe from cancer and this capacity is lost once p53 mutates. A study by examiners at the National Centre for Cell Science (NCCS) in Pune and their agents at the University of Massachusetts Medical School (UMMS) has recognized a lesser-known protein called FBXO31, which shows a key part in keeping p53 protein levels raised in a cell.
In a most important discovery that may significantly impact how cancers are cured in the future, researchers at a national lab in Pune and their contemporary part in the US have found a way to turn up the making of a key anti-cancer biomolecule – a protein called p53 that helps in cracking the cancer code.
The p53 is an amazing protein; often mentioned as “guardian of the genome”, it in fact stands between cancer and us. But once cancer attacks the roots, its level goes down tremendously or it mutates and becomes incompetent to its self-protective functions.